GoLYTELY Bowel Prep Instructions for Colon Surgery

These instructions are for patients preparing for colon surgery with Dr. Aisha Akhtar, a board-certified colon and rectal surgeon in Phoenix, Arizona.

Please follow the instructions given directly by our office. Medication holds, bowel preparation timing, antibiotics, and day-of-surgery instructions may be adjusted based on your medical history and surgical plan.

Important: This page is based on colon surgery preparation instructions. Do not use these instructions for a routine colonoscopy unless our office specifically tells you to do so.

Clear liquid diet

The day before your procedure, you will start a clear liquid diet at the time instructed by our office.

Clear liquids may include:

  • water
  • coffee or tea without milk or cream; sugar is acceptable
  • soft drinks such as 7UP, Sprite, orange soda, or ginger ale
  • Gatorade or Powerade
  • Kool-Aid
  • strained fruit juices without pulp
  • sparkling water
  • chicken, beef, or vegetable broth or bouillon
  • hard candies
  • Jell-O without fruit or toppings
  • popsicles

Do not drink or eat anything colored red or purple. Any other flavor is acceptable unless our office gives you different instructions.

Medications to stop 7 days before surgery

You may need to stop the following medications and supplements 7 days before surgery, unless our office gives you different instructions:

  • GLP-1 medications, including semaglutide, tirzepatide, and dulaglutide
  • ibuprofen
  • NSAIDs
  • gout medications
  • glucosamine/chondroitin
  • vitamin E
  • ginseng
  • St. John’s wort
  • black cohosh
  • garlic supplements
  • herbal supplements

Do not stop prescribed medications unless instructed by Dr. Akhtar, your prescribing clinician, or the surgical team.

Medications to stop 5 days before surgery

You may need to stop the following medications 5 days before surgery:

  • aspirin
  • Coumadin/warfarin
  • Plavix/clopidogrel

If you take Coumadin/warfarin or Plavix/clopidogrel, speak with your prescribing physician before stopping these medications.

Diabetes medication instructions

If you use insulin, follow the individualized instructions provided by your surgical team.

For Metformin/Glucophage, do not take it the night before your procedure or the morning of your procedure, unless our office gives you different instructions.

Medications on the day of surgery

On the day of your procedure, do not take diuretics, including:

  • Lasix/furosemide
  • hydrochlorothiazide
  • Aldactone/spironolactone
  • Diovan HCT

On the day of your procedure, do take your heart or blood pressure medications, unless you were given different instructions.

GoLYTELY bowel preparation

The afternoon before your procedure, you will perform bowel preparation to clear out the bowel.

GoLYTELY is a prescription bowel preparation. The prescription will be sent to your pharmacy. You will receive a large container with powder inside.

Mixing instructions

At 12:00 PM, mix the GoLYTELY according to the instructions provided with the medication, then refrigerate it.

Drinking instructions

At 6:00 PM, start drinking the mixture.

Drink about 1 glass every 15 minutes until the mixture is gone.

Antibiotics and nausea medication

You will need to take two antibiotics the day before your procedure.

Neomycin

Take neomycin 500 mg, 2 tablets by mouth at:

  • 1:00 PM
  • 2:00 PM
  • 10:00 PM

Metronidazole

Take metronidazole 500 mg, 1 tablet by mouth at:

  • 1:00 PM
  • 2:00 PM
  • 10:00 PM

Taking antibiotics on an empty stomach can sometimes cause nausea. Our office may also prescribe nausea medication for you to keep available if needed.

Ondansetron/Zofran

Take ondansetron/Zofran 4 mg by placing 1 tablet on the tongue and allowing it to dissolve.

You may take this every 6 hours as needed for nausea.

Bathing before surgery

It is recommended that you bathe the night before and the morning of your procedure to help lower the risk of infection.

The preferred soap is HIBI-CLENS or chlorhexidine gluconate, also called CHG. This can usually be purchased at most pharmacies. You will need at least a 4-ounce bottle.

If you are unable to obtain HIBI-CLENS, you may use an antibacterial soap such as Dial, Lever, or Safeguard. Body wash or bar soap is acceptable.

When bathing:

  • wash from the neck down
  • leave the soap on your skin for 3 to 5 minutes before rinsing
  • do not wash with your regular soap after using the antibacterial soap

Morning of surgery reminders

The morning of your procedure:

  • do not shave the surgery site
  • bring your rescue inhaler if you use one
  • if you use an insulin pump, leave it on and bring your pump supplies
  • if you use a CPAP or BiPAP machine, you may be asked to bring it with you
  • do not wear contact lenses
  • do not wear makeup
  • remove all colored nail polish
  • do not wear jewelry
  • do not apply lotions, perfumes, powders, or deodorant after using antibacterial soap on the day of surgery
  • wear casual, comfortable, loose-fitting clothes
  • you may be asked to remove dentures before surgery; the hospital will provide a denture cup and return them after surgery

Surgery center call

If you have not heard from the surgery center by noon the day before your procedure, please call our office.

When to call the office

Please contact the office if:

  • you are unsure whether these instructions apply to you
  • you cannot tolerate the bowel prep
  • you vomit repeatedly after starting the prep
  • you did not receive your GoLYTELY prescription
  • you did not receive your antibiotic prescriptions
  • you have questions about blood thinners, diabetes medications, GLP-1 medications, or heart medications
  • you have not heard from the surgery center by noon the day before surgery
  • you develop fever, severe abdominal pain, chest pain, shortness of breath, or worsening weakness

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Frequently Asked Questions

Is this GoLYTELY prep for colonoscopy or colon surgery?

These instructions are for colon surgery preparation. They include antibiotics, bathing instructions, and surgery-specific reminders. Do not use this as routine colonoscopy prep unless our office specifically instructs you to do so.

When do I start the clear liquid diet?

Start the clear liquid diet at the time provided by our office, usually the day before your procedure.

Can I drink red or purple liquids?

No. Avoid red or purple liquids, gelatin, popsicles, or candies because they can interfere with visibility during the procedure.

When do I mix and drink GoLYTELY?

Mix GoLYTELY at 12:00 PM according to the medication instructions, then refrigerate it. Start drinking it at 6:00 PM, about 1 glass every 15 minutes, until it is gone.

Do I need antibiotics before surgery?

Yes, if prescribed as part of your colon surgery prep. The listed antibiotics are neomycin and metronidazole, taken the day before surgery.

What should I do if the antibiotics make me nauseated?

Our office may prescribe ondansetron/Zofran. Take it as directed if nausea occurs.

Should I stop my blood thinners?

Do not stop blood thinners without guidance. If you take Coumadin/warfarin, Plavix/clopidogrel, aspirin, or another blood thinner, confirm the plan with your prescribing clinician and surgical team.


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